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iCE™ platforms perform imaged capillary isoelectric focusing (cIEF) and capillary electrophoresis sodium dodecyl sulfate (CE-SDS) for reproducible, quantitative analysis of identity, purity, and heterogeneity profiles for your therapeutic proteins. And they do it fast—we're talking results in 15 minutes or less per sample! You'll also get high resolution, full-on automation, and none of the hassles that come with other IEF techniques. Maurice platforms also automate size separations for you, so you'll get robust and quantitative analysis for your monoclonal antibodies too.

ProteinSimple is now a brand in the Bio-Techne family of brands that includes R&D Systems, Novus Biologicals and Tocris. As a company, Bio-Techne has developed, manufactured and sold biotechnology products, clinical calibrators and controls, and consumables for protein analysis—and now analytical instrumentation and consumables through ProteinSimple.

iCE Instruments for cIEF and CE-SDS

Maurice​ One-stop cIEF and CE-SDS​ Purity, identity, and heterogeneity analysis​

Maurice

One-stop cIEF and CE-SDS

Purity, identity and heterogeneity analysis

Maurice S.​ Ready-to-go CE-SDS or CE-SDS PLUS​ Simplifies size separation workflows​

Maurice S.

Ready-to-go CE-SDS or CE-SDS PLUS

Simplifies size separation workflows

cIEF and CE-SDS with iCE

Maurice C.

cIEF data in a snap

Identity and charge heterogeneity

iCE3​ Current standard for cIEF protein charge heterogeneity analysis​

iCE3

Current standard for cIEF protein charge heterogeneity analysis

Maurice consumable cartridges by ProteinSimple a Bio-Techne brand

iCE Consumables

You can now order consumables for Maurice and iCE online

Which imaged cIEF/CE-SDS system is right for you?

* with Alcott Autosampler

System

Maurice

Maurice C.

Maurice S.

iCE3

cIEF Charge Application

Yes

Yes

No

Yes

CE-SDS Size Application

Yes

No

Yes

No

Absorbance Detection

Yes

Yes

Yes

Yes

Fluorescence Detection

Yes

Yes

No

No

Onboard Mixing for Sample Prep

Yes

Yes

No

Yes*

Description

cIEF Specification

CE-SDS Specification

Minimum Sample Volume

50 µL

50 µL

Sample Delivery

Vacuum

Electrokinetic

Typical Separation Time

6-10 min (molecule-dependent)

UV Absorbance at 220 nm

Detection Capability

Pre-focusing: 1500 V, focusing: 3000 V

Separation: 5750 V

Sample Injections per Cartridge

100 guaranteed, 200 maximum

100 guaranteed, 200 maximum for CE-SDS, 500 maximum for CE-SDS PLUS

Maximum Sample Injections per Batch

100

48

pI/Size Range

2.85-10.45

10-270 kDa

pI/Sizing CV

1%

≤2%

CV for Peaks >10% Composition

≤5% (Intra-batch), ≤6% (Inter-batch)

N/A

pI/Sizing Resolution

2 logs

2 logs

Dynamic Range

2 logs

2 logs

Linearity

>0.995

>0.995

Sensitivity (LOD)

0.7 µg/mL (Native fluorescence) 3.0 µg/mL (Absorbance) (Values based on a monoclonal antibody)

0.3 µg/mL (Value based on internal standard)

Sample Tray Options

96-well plates or 48 vials

96-well plates or 48 vials

Power

100 V-240 V (AC), 50/60 Hz, 500 W

100 V-240 V (AC), 50/60 Hz, 500 W

Temperature Control Range

4-25 °C

4-25 °C

Dimensions

44cm H x 42cm W x 61cm D

44cm H x 42cm W x 61cm D

Weight

46 kg (100 lb)

46 kg (100 lb)

iCE Applications

Bioprocessing

Bioprocessing

Whether it is during clone selection or final product characterization, use a hassle-free, robust, and fast method to characterize the charge and size profiles of your therapeutic.

CE-SDS

CE-SDS

Get automated, reproducible, and high-throughput CE-SDS analysis in as little as 25 minutes per sample.

Cell & Gene Therapy

Cell & Gene Therapy

Next-generation analytical instrumentation to help improve and accelerate your cell and gene therapy workflows.

Protein Charge Heterogeneity

Protein Charge Heterogeneity

High-quality absorbance and native fluorescence give you charge heterogeneity data for even the most complex proteins with automated, whole-column cIEF.

Protein Stability and Formulation Testing

Protein Stability and Formulation Testing

Understand the impact of protein changes on drug safety and efficacy and develop the best formulation for your therapeutic with cIEF analysis.

Protein and Antibody Characterization

Protein & Antibody Characterization

Rapidly and accurately monitor the charge and molecular weight heterogeneity of your proteins, two critical properties that inevitably change during development.

Post-translation Modification

Post-translation Modification

To know if your proteins have undergone deamidation, oxidation, glycation, or another other post-translational modification, get accurate data on their changing isoelectric points.

Biosimilars

Biosimilars

Gain confidence in your biosimilars by getting accurate, high-quality data on the charge and size profiles of your proteins and antibodies.

Vaccine

Vaccine Development

Whether you’re working with LNPs or viral vectors, confirm their charge heterogeneity, identity, and purity, and proceed confidently with your vaccine development.